Laboratoires Expanscience

Hand osteoarthritis: Biological tests

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Hands: Biological tests


Some biological tests may be requested by your doctor to confirm the diagnosis of osteoarthritis.


These are: 

  • blood tests, 
  • synovial fluid tests, 
  • histological examinations.


There are no specific biological signs of osteoarthritis.


For several years, some research teams have been looking for products of the metabolism of articular cartilage (found in synovial fluid, urine or blood of people with osteoarthritis), which could be biological indicators of osteoarthritis. Currently, research has not yet been completed, but the findings are promising.

They are of little interest in osteoarthritis They can simply provide additional information to rule out an alternative diagnosis, like another joint disease.

The appearance of the synovial fluid or joint fluid, is called "mechanical" (aspect of cooking oil), that is to say clear, viscous, containing less than 1,000 white blood cells / mm3, with <50% polynuclear cells.


It is not uncommon during the inflammatory flare-ups to get an increase in white blood cells by up to 2,000 / mm3.

A synovial biopsy may be requested by your doctor. The latter has the sole purpose of eliminating the possibility of an associated pathology, especially when osteoarthritis affects only one joint.