Laboratoires Expanscience

Knee osteoarthritis: Risk factors

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Knee: Risk factors


The risk factors presented below are the most frequently observed for osteoarthritis of the knee. However, they should not be regarded as systematic. Each individual is different, as is their environment (such as occupation, leisure time activities, sports, etc.), hence these risk factors do not exist in all individuals. Only your doctor can advise you about your own personal risk factors regarding osteoarthritis.

The most common risk factors are:  

  • Gender : knee and digital osteoarthritis are more common in women.
  • Being overweight is a risk factor especially in women and after the menopause.
  • Architectural abnormalities,
  • Joint trauma
  • Heredity,
  • Intense physical exercise
  • Microtrauma (work, etc.),
  • Metabolic diseases (infections, rheumatism, osteonecrosis, etc.)

Knee and digital osteoarthritis are more common in women. Hormonal factors are suspected without formal proofBeing overweight is a risk factor especially in women and after the menopause.Architectural abnormalities, joint trauma (meniscal tears or cruciate ligaments, etc.)Heredity, Intense physical exerciseMicrotrauma (work, etc.), metabolic diseases (infections, rheumatism, osteonecrosis, etc.)

It is known that women, especially after the menopause are more prone to osteoarthritis than men. This is particularly true for osteoarthritis of the fingers, knees and osteoarthritis affecting several joints.


Osteoarthritis of the hip, if not more frequent, is more painful in women.


Lastly, the number of joint prostheses (especially of the hip) is greater in women.


It is thought that sex hormones may be involved, but currently no hormonal treatment administered after the menopause has shown a protective effect against osteoarthritis.

We are now certain that obesity is a situation that promotes the development of osteoarthritis.


Thus, for the knee joint, being overweight exposes you in the future to a greater risk of knee osteoarthritis.


Similarly, in cases of already confirmed osteoarthritis of the knee, weight gain leads to increased cartilage damage and symptoms.


The Framingham study specifies that a loss of 5 kg in the previous 10 years, can reduce the risk of knee osteoarthritis in women by 50%.


The risk of osteoarthritis is not only due to mechanical reasons (caused by being overweight), but also endocrine and metabolic factors. Studies have demonstrated a connection between osteoarthritis and high blood sugar.


If we can more easily understand the role of weight in the occurrence of osteoarthritis of the knee and hip, its role in osteoarthritis of the hands is more surprising. Researchers are currently looking for factors in the blood of obese people that could explain the deterioration of the cartilage.


To find out how to calculate your ideal weight, click here

Local factors: Architectural abnormalities


Whether congenital or acquired structural abnormalities will alter mechanical stress and promote the development of secondary osteoarthritis.


This may include dysplasia, protrusions, subluxations or acquired anomalies such as coxa plana and slipped femoral epiphysis in childhood or osteonecrosis.


Genu varum is more common than genu valgum, it can be idiopathic or secondary.


Destructive inflammatory diseases may also alter some joint mechanisms.


Local factors: Joint trauma


Often a fracture, dislocation or tendon injury can lead to osteoarthritis.



Heredity seems to play a part in osteoarthritis. Numerous epidemiological studies have established that there is a family character for osteoarthritis of the fingers and hip. Hence, a woman risks having osteoarthritis of the fingers when her mother or maternal or paternal aunt suffers from it.


Studies of homo- and heterozygous twins evaluated the genetic contribution at around 39 to 45% with the remainder related to environmental factors.


Local factors: Physical exercise


There is a close connection between exercise and osteoarthritis, but not always in the sense one might think.

Keeping moving is essential in osteoarthritis Exercise, provided that it remains appropriate to your condition and ability has a beneficial effect on the joints affected by osteoarthritis:

  • The joints keep their flexibility;
  • Muscle strength is maintained or even increased;
  • Joint stability is ensured;
  • Endurance in everyday activities is assured.

You must therefore keep up a regular exercise routine while avoiding overworking your joints.
Simply walking (at least one hour, three times a week) enables maintaining joints and significantly reducing pain.

However in case of pain, it is useless to deny it and continue as if nothing were wrong in relation to the activity causing it: it could worsen cartilage damage. You must therefore adapt your attitude to maintaining your activities as much as possible and paying heed to any pain if it occurs.


You should also be aware that a moderate amount of sports activities does not increase the risk of osteoarthritis even in elderly subjects. You can read the advice on sport in the following section: Everyday life

However, intensive sports may be a cause of developing osteoarthritis. Indeed, the latter often leads to trauma and overexertion of joints.

This relates in particular to: football and rugby for the knees, dance for the hips and baseball for the elbows and shoulders.

Local factors: Microtrauma


Microscopic lesions caused by too much stress can traumatize some joints and lead under certain conditions to the onset of osteoarthritis.

This is the case not only in certain occupations in which subjects are subjected to mechanical vibration and repeated shocks (users of pneumatic drills, drivers of construction equipment), but also when it is necessary to make repetitive movements.

Cases of knee osteoarthritis also occur in people working in a kneeling position (tile layers).


Metabolic diseases :


Abnormalities of certain metabolisms can lead to a deposit of microscopic crystals in the joints. This is the case in the disease that everyone knows: gout where the crystals are composed of uric acid.

Hence, other crystals may occur such as those of calcium phosphate compounds that are deposited on the surface of joints in chondrocalcinosis, or hydroxyapatite crystals that tend to be deposited in the tendons.

It is in fact the repetition of inflammatory flare-ups triggered by these deposits that promotes the development of osteoarthritis in the joint in question.


For a better understanding of the phenomena that occur in the joint in osteoarthritis take a look at the section: Understanding

Hence, these diseases may be responsible for diffuse osteoarthritis involving joints spared by primitive osteoarthritis (wrists, elbows, shoulders, ankles). The same is true for other diseases due to excess weight: hemochromatosis, Wilson's disease, Paget's disease and chondrodysplasia.